Colorectal cancer (CRC) is the key leading cause of highmorbidity and mortality worldwide. Surgical excision is the most effective\ntreatment for CRC. However, stress caused by surgery response can destroy the body�s immunity and increase the likelihood of\ncancer dissemination and metastasis. Anesthesia is an effective way to control the stress response, and recent basic and clinical\nresearch has shown that anesthesia and related drugs can directly or indirectly affect the immune system of colorectal cancer\npatients during the perioperative period.Thus, these drugs may affect the prognosis ofCRCsurgery patients. This reviewis intended\nto summarize currently available data regarding the effects of anesthetics and related drugs on perioperative immune function and\npostoperative recurrence and metastasis in CRC patients. Determining the most suitable anesthesia for patients with CRC is of\nutmost importance.
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